SUN-023 EXTRACELLULAR VESICLES-ENCAPSULATED IL-10 AS NOVEL NANOTHERAPEUTICS AGAINST ISCHEMIC AKI

Extracellular Vesicles as Neprilysin Delivery Syemory Improvement of Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. These vesicles are secreted from various cells such as mesenchymal stem cells (MSCs) and can pass through biol...

Extracellular Vesicles as Neprilysin Delivery Syemory Improvement of Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. These vesicles are secreted from various cells such as mesenchymal stem cells (MSCs) and can pass through biol...

Vaccination of C57BL/10 mice against cutaneous leishmaniasis. Use of purified gp63 encapsulated into niosomes surfactants vesicles: a novel approach.

Extracellular vesicles as novel carriers for therapeutic molecules

Extracellular vesicles (EVs) are natural carriers of biomolecules that play central roles in cell-to-cell communications. Based on this, there have been various attempts to use EVs as therapeutic drug carriers. From chemical reagents to nucleic acids, various macromolecules were successfully loaded into EVs; however, loading of proteins with high molecular weight has been huddled with several p...

Extraction and biological evaluation of Mycobacterium kansasii extracellular vesicles as a vaccine candidate against mycobacterial pulmonary infections

Introduction: Extracellular vesicles (EVs) are bacterial products with diverse biological roles. Like many microorganisms, Mycobacterium kansasii as a nontuberculous mycobacteria (NTM), can naturally release EVs. The aim of the present study was the extraction and biological evaluation of M. kansasii as a vaccine candidate against mycobacterial pulmonary infections. Methods: After bacterial cul...